Role of Oxidative Stress in Assessment of Damage Induced by Lead Acetate in Mice Gastrocnemius Muscle

Anita Thakur; Sushma Sharma

Title:
Role of Oxidative Stress in Assessment of Damage Induced by Lead Acetate in Mice Gastrocnemius Muscle

Authors:
Sushma Sharma | Anita Thakur
DOI:
https://doi.org/10.31142/ijtsrd18927

Cite This Article :

Sushma Sharma | Anita Thakur "Role of Oxidative Stress in Assessment of Damage Induced by Lead Acetate in Mice Gastrocnemius Muscle" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-1, December 2018, pp.47-50, URL: https://www.ijtsrd.com/papers/ijtsrd18927.pdf

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Abstract :
Heavy metal deposition has increased due to the anthropogenic activities leading to heavily polluted areas worldwide. The objective of present study was to evaluate the effect of lead acetate [Pb(C2H3O2)2] on antioxidant enzyme activities in gastrocnemius muscle of mice. Lead is a toxic heavy metal widely distributed in the environment due to its role in modern industry. Normal healthy looking mice showing no sign of morbidity were divided into three groups. Group I was designated as control whereas group II and group III received lead acetate having doses 10 mg/kg body weight of lead acetate, daily and 150 mg/kg body weight of lead acetate, weekly respectively. Study was performed at 40 and 80 days stages. Lead acetate significantly decreases antioxidant enzymes and increase oxidative stress along with muscle tissue damage.

Keywords :
Lead acetate, gastrocnemius muscle, Antioxidant enzymes

Publication Details:

Unique Identification Number : IJTSRD18927

Published In : Volume-3 | Issue-1, December 2018

Page Number(s) : 47-50

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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